The present invention relates to a composition capable of usefully preventing and treating leaky gut syndrome or non-steroidal anti-inflammatory drug (NSAID)-induced leaky gut syndrome, the composition containing potassium-competitive acid blocker (p-cab) as an active ingredient.La présente invention concerne une composition capable de prévenir et de traiter efficacement le syndrome de lintestin perméable ou le syndrome de lintestin perméable induit par un médicament anti-inflammatoire non stéroïdien (AINS), la composition contenant en tant que principe actif un agent bloquant lacide par compétition avec le potassium (p-cab, pour "potassium-competitive acid blocker").본 발명은 칼륨 경쟁적 위산분비억제제(Potassium-Competitive Acid Blocker, p-cab)를 유효성분을 함유하는 장 누수 증후군, 비스테로이드성 항염제(NSAID)에 의해서 유발되는 장 누수 증후군을 유용하게 예방 및 치료할 수 조성물에 관한 것이다.