ENHANCED REGULATORY T CELLS TARGETED TO SITES OF INFLAMMATION WITH CHIMERIC ANTIGEN RECEPTORS AND EXPRESSING FACTORS THAT ENHANCE VIABILITY OF PANCREATIC CELLS
Everett Hurteau Meyer,Panagiota Iliopoulou,Antonio Pierini,Seung K. Kim
申请号：
US15466591
公开号：
US20170274095A1
申请日:
2017.03.22
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Regulatory T cells (Treg) are engineered to express a chimeric antigen receptor (CAR), that specifically binds to a non-endogenous antigenic moiety and are administered in combination with an effective dose of targeting antibodies, which antibodies (i) bind to an antigen localized at a site of inflammation and (ii) are labeled with the antigenic moiety, wherein inflammation is decreased at the targeted site.
