Relates to a purification method of one or more CANNABINOIDS from plant material that includes: a) the first hatching Plant material with a Polar Solvent to form a First Solvent mixture in which one or more CANNABINOIDS is extracted (b) reduce the volume of the Prim Solvent mixture was approximately 50% of the original volume (c) the first Incubation mixture NetworkAmong these ucida - 40oC so that realize one or more CANNABINOIDS hatching (d) one or more compounds CRYSTALLIZED with a Second non-polar Solvent to form a Second mixture Solvent that Dissolves in at least 50% of CANNABINOIDS CRYSTALLIZED according to The hatching (e) Da Solvent mixture between these - 40oC so that realize one or more CANNABINOIDS PuriIfied. Additionally, the method includes PURIFYING CANNABINOIDS CRYSTALLIZED using Filtration leads to collect a Mother Liquor and the liquor to incubate these - 40oC so that realize one or more CANNABINOIDS. It also relates to a Pharmaceutical composition.This method allows to obtain Purified compounds useful in the treatment of schizophrenia, swelling, seizures, among others.Se refiere a un metodo de purificacion de uno o mas cannabinoides a partir de material vegetal que comprende: a) incubar el material vegetal con un primer disolvente no polar para formar una primera mezcla de disolventes en el cual se extrae uno o mas cannabinoides b) reducir el volumen de la primera mezcla de disolvente a aproximadamente 50% del volumen original c) incubar la primera mezcla reducida entre -70°C a 40°C de manera que cristalice uno o mas cannabinoides d) incubar uno o mas cannabinoides cristalizados con un segundo disolvente no polar para formar una segunda mezcla de disolvente en el que se disuelve al menos el 50% de los cannabinoides cristalizados e) incubar la segunda mezcla de disolventes entre entre -70°C a 40°C de manera que cristalice uno o mas cannabinoides purificados. Adicionalmente, el metodo comprende purificar los cannabinoides cristalizados usando la filtr
