The present invention relates to novel therapeutic approaches for treating or preventing diseases in mammals, particularly in human subjects, using a PLA2-GIB cofactor, or a modulator of a PLA2-GIB cofactor.本發明係關於使用PLA2-GIB輔因子或PLA2-GIB輔因子之調節劑治療或預防哺乳動物、尤其人類個體之疾病之新穎治療方法。