The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.本發明係關於一種囊腫性纖維化跨膜傳導調節因子(「CFTR」)之調控因子、其組合物及與其有關之方法。本發明亦係關於一種使用CFTR之調控因子治療疾病之方法。