SANIERE, LAURENT RAYMOND MAURICE,HUCK, JACQUES,DYKES, GRAEME JAMES,SCHMITT, BENOIT ANTOINE,BLANC, JAVIER,BUTLER, ANNA SARA,BONNATERRE, FLORENCE MARIE-EMILIE,BEAUMONT, STEPHANE NICOLAS ALAIN
申请号：
TW103127966
公开号：
TW201536783A
申请日:
2014.08.14
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.本發明揭示式I化合物，□其中R1、R2、R3、R4、L及X係如本文中定義。本發明係關於化合物、其製造方法、包含該等化合物之醫藥組合物，及其用於預防及/或治療發炎病況、2型糖尿病、神經疾病及/或神經退化性疾病、自體免疫疾病、增生性疾病(特別是轉移性疾病及/或癌症)、異常血管發生相關之疾病、軟骨降解及/或軟骨穩態破壞、特別是用於預防及/或治療癌症之用途。本發明亦揭示使用該等化合物之治療方法，藉由投與本發明之該化合物用於預防及/或治療該等疾病。
