Jacques HUCK;Stéphane Nicolas Alain BEAUMONT;Javier BLANC;Graeme James DYKES;Laurent Raymond Maurice SANIÈRE;Anna Sara BUTLER;Benoit Antoine SCHMITT;Florence Marie-Emilie BONNATERRE
发明人:
Laurent Raymond Maurice SANIÈRE,Jacques HUCK,Graeme James DYKES,Benoit Antoine SCHMITT,Javier BLANC,Anna Sara BUTLER,Florence Marie-Emilie BONNATERRE,Stéphane Nicolas Alain BEAUMONT
申请号：
US14461629
公开号：
US20150080391A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention discloses compounds according to Formula I:wherein R1, R2, R3, R4, L, and X are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.
