ANDREA VAUPEL,FRANÇOIS GESSIER,GUIDO BOLD,JOANNA HERGOVICH LISZTWAN,JOERG KALLEN,KEIICHI MASUYA,PASCAL FURET
申请号：
BR112012008075
公开号：
BR112012008075A2
申请日:
2010.08.24
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The invention relates to tetra-substituted heteroarylic compounds of the formula (I) wherein X1, X3 and X4 are independently C or N, Y is C&mdash；H, N&mdash；H or N, wherein the total number of nitrogen atoms represented by X1, X3, X4 and Y is 1 or 2； rings A and B are independently selected from phenyl or pyridyl； R1, R4, R&prime；, R&Prime；, n and m are as defined herein. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.
