A physiological signal sensing device comprises a sound transmission component, a sound collecting component, and an audio source receiving device. The sound transmission component comprises a plurality of independent closed hole structures that are not communicated with each other for generating a sound resonance effect, so that the sound waves of the microphonics from heart sounds, breathing vibration or organ sounds are transmitted in the sound transmission component by directly or indirectly contacting users body. The sound collecting component comprises a first end and a second end, wherein the first end is in contact with the surface of the sound transmission component and is communicated with the second end by a through hole. The audio source receiving device comprises a receiving end and a sensing element, in which the receiving end is connected with the second end of the sound collecting component for receiving the sound waves transmitted by the sound transmission component, so as to achieve the purpose of physiological signal sensing.一種生理訊號感測裝置,包含傳聲件、集音件及音源接收裝置。傳聲件包含複數個獨立不相互連通之閉孔結構,能產生聲共振效應,透過與使用者的身體直接或間接接觸時,將心音、呼吸震動或臟器音等微動之聲波於傳聲件中傳遞。集音件包含第一端部及第二端部,其中一端部接觸傳聲件表面,與第二端部之間以貫孔連通。音源接收裝置包含接收端及感測元件,接收端連接集音件的第二端部以接收該傳聲件傳播之聲波,達到偵測生理訊號之目的。100‧‧‧生理訊號感測裝置110‧‧‧傳聲件120‧‧‧集音件130‧‧‧音源接收裝置140‧‧‧凹緣
