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Materials and methods for prevention and treatment of microbial mediated epithelial diseases
专利权人:
ザ ユニヴァーシティー オヴ シカゴ
发明人:
アルヴァーディー ジョン シー エム ディー
申请号:
JP2004555237
公开号:
JP5271475B2
申请日:
2002.11.26
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and/or essential pathogen nutrients such as L-glutantine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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