INHIBITION OF HIF-2 HETERODIMERIZATION WITH HIF1 (ARNT)

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专利权人:

发明人:

申请号：

EP13854318.6

公开号：

EP2919770A4

申请日:

2013.11.14

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

Provided is a method of inhibiting heterodimerization of HIF-2α to HIF1β (ARNT) comprising binding certain small molecules to the HIF-2α PAS-B domain cavity but not to HIF1α and inhibiting HIF-2α heterodimerization to HIF1β (ARNT) but not inhibiting HIF1α heterodimerization to HIF1β (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2α heterodimerization inhibitors and also simply as certain small molecules.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/