Refers to a Pharmaceutical composition comprising an agonist of Toll like receptor 7 (TLR7) of formula I or II, where R1 is alkyl, Hydroxy, C1 - C6, among others R2 is Hydrogen,C1 - C6 alkyl, among others R3 is Hydrogen or alkyl of C1 - C6 carbonyl R4 and R5 is Hydrogen, alkyl or alquenilo C2 - C6 C1 - C6, R6 and R7 are Hydrogen, C1 to C6 alkyl -,Among others, R8 are Hydrogen or alkyl of C1 - C6 carbonyl an inhibitor of HBV capsid Assembly of the formula III,Where: R9 is C1 - C6 alkyl phenyl substituted is R10, R11 is Hydrogen, alkyl or C1 - C6 R12 is a heterociclilo monociclico, among others and a pharmaceutically acceptable vehicle.It also refers to a Manufacturing method and a Kit for treatment. Said composition is useful in the treatment of infection by the hepatitis B virus.Referida a una composicion farmaceutica que comprende un agonista de los receptores de tipo Toll 7 (TLR7) de formula I o II, donde: R1 es hidroxi, alquilo C1-C6, entre otros R2 es hidrogeno, alquilo C1-C6, entre otros R3 es hidrogeno o alquil C1-C6 carbonilo R4 y R5 son hidrogeno, alquenilo C2-C6 o alquilo C1-C6 R6 y R7 son hidrogeno, alquilo C1-C6, entre otros R8 son hidrogeno o alquil C1-C6 carbonilo un inhibidor del ensamblaje de la capsida del VHB de formula III, donde: R9 es alquilo C1-C6 R10 es fenilo sustituido R11 es hidrogeno o alquilo C1-C6 R12 es un heterociclilo monociclico, entre otros y un vehiculo farmaceuticamente aceptable. Tambien se refiere a un metodo de fabricacion y a un kit de tratamiento. Dicha composicion es util en el tratamiento de la infeccion por el virus de la hepatitis B.
