The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiment, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions. The below summary is exemplary only, and not limiting. Other embodiment of the disclosed subject matter are possible. Embodiment of the disclosed subject matter can provide techniques relating to portable ex vivo organ care, such as ex vivo liver organ care. In some embodiment, the liver care system can maintain the liver at, or near, normal physiological conditions. To this end, the system can circulate an oxygenated, nutrient enriched perfusion fluid to the liver at or near physiological temperature, pressure, and flow rate.
