PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
发明人:
KIM, HYEUNG RAK,김형락,KIM, A REUM,김아름,KWON, MI SUNG,권미성,CHOI, JAE SUE,최재수,SHIN, TAI SUN,신태선,BYUN, DAE SEOK,변대석,WOO, HEE CHUL,우희철
申请号：
KR1020120038386
公开号：
KR1020120054577A
申请日:
2012.04.13
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A composition containing phlorotannins derived from Ecklonia stolonifera and Ecklonia cava extract is provided to suppress iNOS and COX-2 expression and to prevent and treat inflammatory diseases.CONSTITUTION: A phlorofucofuroeckol A compound of chemical formula I is isolated from Ecklonia stolonifera and Ecklonia cava extract. A method for isolating and purifying the compound of chemical formula I comprises: a step of extracting ethanol extract of Ecklonia stolonifera and Ecklonia cava with n-hexane to prepare hexane water soluble extract a step of extracting the hexane water soluble extract with ethyl acetate. The Ecklonia stolonifera and Ecklonia cava extract includes crude extract or non-polar solvent soluble extract. The crud extract is prepared using water, ethanol, methanol, butanol, or mixture thereof.COPYRIGHT KIPO 2012본 발명은 곰피와 감태 추출물 유래의 플로로탄닌을 유효성분으로 함유하는 염증억제용 조성물에 관한 것으로, 특히 에탄올 또는 메탄올 추출물 중 헥산과 에틸아세테이트 획분과 에틸아세테이트 획분에서 분리된 phlorofucofuroeckol A (플로로푸코푸로에콜 에이)는 염증매개인자인 iNOS와 COX-2 발현억제와 이 효소에 의해 생성되는 NO와 PGE2의 생성억제에 효능이 있으므로 염증과 관련된 질병을 예방 및 치료하는데 뛰어난 효과가 있다.
