INACTIVATION THERMIQUE DE ROTAVIRUS

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专利权人:

AS REPRESENTED BY THE SECRETARY;THE GOVERNMENT OF THE UNITED STATES OF AMERICA; DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人:

JIANG, BAOMING,GLASS, ROGER, I.,SALUZZO, JEAN-FRANCOIS

申请号：

EP08829810

公开号：

EP2197487A4

申请日:

2008.09.04

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.

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