JIANG BAOMING,GLASS&NBSP ROGER&NBSP I,SALUZZO&NBSP JEAN FRANCOIS
申请号：
IN2239/DELNP/2010
公开号：
IN281079B
申请日:
2010.03.31
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50oC-80oC, inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.
