The United States of America; Department of Health and Human Servic; as represented by the Secretary
发明人:
Baoming Jiang,Roger I. Glass,Jean-Francois Saluzzo
申请号：
US16722393
公开号：
US20200121782A1
申请日:
2019.12.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic and retains a substantially intact rotavirus particle structure. Vaccine compositions and methods of vaccinating a subject against rotavirus are provided which include generation and use of thermally inactivated rotavirus.
