METZ, JR., WILLIAM ARTHUR,麦兹赭,麥茲赭,DING, FA-XIANG,丁法祥
申请号：
TW094128283
公开号：
TWI357897B
申请日:
2005.08.19
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Methods for the treatment of a patient suffering from a disease or disorder ameliorated by inhibition of casein kinase I&egr； activity comprising the administration of a compounds of formula (I) and formula (II) as inhibitors of human casein kinase I&egr；, and methods of using the compounds of formula (I) and formula (II) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. The R-group substituents are defined herein and pharmaceutical compositions comprising compounds of formula (I) or formula (II) useful in the claimed methods of treatment are also disclosed.本發明揭示及請求作為人類酪蛋白激酶Iε抑制劑的結構式為(I)和結構式為(II)的化合物以及利用該結構式為(I)和結構式為(II)的化合物治療包括情緒障礙和睡眠障礙在內的中樞神經系統疾病和異常的方法。本發明還揭示及請求一類含有結構式為(I)或結構式為(II)之化合物的醫藥組成物。
