The present invention provides compound of formula I, is treating the application in disease relevant to phosphatidyl-inositol 3-kinase and illness such as cancer including the pharmaceutical composition of the compound and the compound. The application further relate to illness relevant to histidine deacetylase and with both histidine deacetylase and phosphatidyl-inositol 3-kinase relevant illness treatment.本發明提供式I化合物，包括該化合物的藥物組合物，以及該化合物在治療與磷脂酰肌醇3-激酶相關的疾病和病症如癌症中的應用。本申請還涉及與組氨酸脫乙酰化酶相關的病症以及與組氨酸脫乙酰化酶和磷脂酰肌醇3-激酶兩者相關的病症的治療。
