JOSEPH LAWRENCE ZIELINSKI,JOHN VRETTOS,QIN JI,SUBASH PATEL
申请号：
MX2012007320
公开号：
MX2012007320A
申请日:
2010.12.21
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The present invention provides a tablet comprising a hydroxypropylcellulose and an active ingredient selected from compounds of Formula (I) and salts thereof: wherein R1represents CF3, CHF2, CH2F, CH3CHF-, CH3CF2-, ethyl or iso-propyl and R2represents alkyl substituted by one or more substituents, the substituents being selected from the group consisting of halogen, nitro, cyano, acyl, hydroxy, oxo (=0), alkoxy, cycloalkoxy, acyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, formyl, acylamino, alkoxycarbonylamino or R2 represents heterocyclylalkyl substituted by one or more substituents, the substituents being selected from the group consisting of halogen, nitro, cyano, hydroxy, alkoxy, alkylcarbonyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, alkoxycarbonylamino, or R2represents phenyl substituted by one or more substituents, the substituents being selected from the group consisting of cyano, hydroxy, alkanediyl, alkenediyl, alkoxy, hydroxyalkyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonylamino, or R2represents heterocyclyl optionally substituted by one or more substituents, the substituents being selected from the group consisting of halogen, hydroxy, amino, nitro, cyano, alkyl, hydroxalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, acyl, alkoxy, acyloxy, alkoxycarbonyloxy, amino, alkylamino, dialkylamino, acylamino, alkoxycarbonylamino and whereby the heterocycle is bound to the phenyl ring by a carbon-atom. The invention also provides a process for preparing the above tablet.La presente invención proporciona una tableta que comprende una hidroxi-propil-celulosa y un ingrediente activo seleccionado a partir de los compuestos de la fórmula (I), y sales de los mismos: (Ver Formula) en donde: R1 representa CF3, CHF2, CH2F, CH3CHF-, CH3CF2-, etilo, o iso-propilo, y R2 representa alquilo sustituido por
