RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTOR 1 (ROR1) SINGLE CHAIN FV ANTIBODY FRAGMENT CONJUGATES AND METHODS OF USE THEREOF

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专利权人:

The Regents of the University of California

发明人:

Kipps Thomas J.,Yu Jianqianq

申请号：

US201514973486

公开号：

US2016304619(A1)

申请日:

2015.12.17

申请国别(地区):

美国

年份:

2016

代理人:

摘要：

Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/