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DIESTERS PHOSPHONATES NUCLÉOSIDIQUES ACYCLIQUES POUR LE TRAITEMENT DU VIRUS DU PAPILLOME HUMAIN, DE LA NÉOPLASIE INTRAÉPITHÉLIALE CERVICALE, DE LA NÉOPLASIE INTRAÉPITHÉLIALE ANALE OU DE LA NÉOPLASIE INTRAÉPITHÉLIALE VULVAIRE
专利权人:
The Regents of the University of California
发明人:
申请号:
EP18179904.0
公开号:
EP3401320A1
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The present disclosure relates, inter alia, to a compound of Formula (la):or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein:BNuc(a) is selected from the group consisting of:La is an unsubstituted C13-29 heteroalkyl;Ra is selected from the group consisting of an unsubstituted C1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C1-6 alkyl), a substituted or unsubstituted heteroaryl(C1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C1-6alkyl);Xa is hydrogen, an unsubstituted C1-6alkyl, a halogen substituted C1-6alkyl, a hydroxy substituted C1-6 alkyl or an unsubstituted C1-6 alkoxy;wherein alkyl is fully saturated; andwherein the substituent is selected from the following moieties: -OH, -NH2, -SH, -CN, -CF3, -NO2, oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.
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