DIESTERS PHOSPHONATES NUCLÉOSIDIQUES ACYCLIQUES POUR LE TRAITEMENT DU VIRUS DU PAPILLOME HUMAIN, DE LA NÉOPLASIE INTRAÉPITHÉLIALE CERVICALE, DE LA NÉOPLASIE INTRAÉPITHÉLIALE ANALE OU DE LA NÉOPLASIE INTRAÉPITHÉLIALE VULVAIRE
The present disclosure relates, inter alia, to a compound of Formula (la):or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein:BNuc(a) is selected from the group consisting of:La is an unsubstituted C13-29 heteroalkyl；Ra is selected from the group consisting of an unsubstituted C1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C1-6 alkyl), a substituted or unsubstituted heteroaryl(C1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C1-6alkyl)；Xa is hydrogen, an unsubstituted C1-6alkyl, a halogen substituted C1-6alkyl, a hydroxy substituted C1-6 alkyl or an unsubstituted C1-6 alkoxy；wherein alkyl is fully saturated； andwherein the substituent is selected from the following moieties: -OH, -NH2, -SH, -CN, -CF3, -NO2, oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.
