A compound having the general formula (I-a) or a pharmacologically acceptable salt thereof. wherein each substituent is defined as follows: R2 represents a group selected from a group of substituents α, R3 represents a hydrogen atom or a C1-C6 alkyl group optionally substituted with a hydroxyl group, Z represents -CH>； = or -N>； =, and R4 represents a group selected from a group of substituents δ, in which the group of substituents α includes: a hydrogen atom, a hydroxyl group, a halogen group, a nitro group, a C1-alkylsulfonyl group -C6, a C1-C6 alkyl halogen group, a C1-C6 alkoxy halogen group, a C1-C6 alkylcarbonyl group, a C1-C6 dialkylamino group, a C1-C6 dialkylaminocarbonyl group, a C1-C6 dialkylaminocarbonyloxy group, a phenoxy group , a C1-C6 alkoxycarbonyl group, a 4-morpholinyl group, a C1-C6 alkylamino group optionally substituted with groups selected from a group of β substituents, a piperidinyl group optionally substituted with groups selected from a group of β substituents, or n piperazinyl group optionally substituted with groups selected from a group of β substituents, a tetrahydropyridinyl group optionally substituted with groups selected from a group of β substituents, a vinyl group optionally substituted with groups selected from a group of β substituents, a C1- alkyl group C6 optionally substituted with groups selected from a group of β substituents, a C1-C6 alkoxy group optionally substituted with groups selected from a group of β substituents, a C1-C6 alkoxy halogen group optionally substituted with groups selected from a group of β substituents, and a C1-C6 alkoxy group C1-C6 alkoxy optionally substituted with groups selected from a substituent group β, in which the substituent group β includes:Un compuesto que tiene la fórmula general (I-a) o una sal farmacológicamente aceptable del mismo. en la que cada sustituyente se define de la siguiente manera: R2 representa un grupo seleccionado de un grupo de sustituyentes &alpha；, R3 representa
