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COMPOSITION PHARMACEUTIQUE
专利权人:
LEK PHARMACEUTICALS D.D.
发明人:
AVANZO, MATEJ,ROZMAN PETERKA, TANJA,LEGEN, IGOR
申请号:
CA2651138
公开号:
CA2651138C
申请日:
2007.05.02
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention relates to pharmaceutical compositions comprising an ester ofolmesartan, such as olmesartan medoxomil. Olmesartan medoxomil is a prodrugthatis hydrolyzed during absorption, but it is not desirable that it hydrolyzesprior toingestion, during storage. A stable formulation comprising an ester ofolmesartan andstearic acid, exhibiting exceptional stability when subject to stressconditions, isdisclosed. Processes for the preparation of such pharmaceutical compositions,aswell as the use of stearic acid to prevent degradation of olmesartanmedoxornil toolmesartan acid in a pharmaceutical composition, are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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