An object is to provide compositions that are safe to humans and animals, can be continually taken on a regular basis, posses anti-fatigue action, and are efficient in preventing or treating fatigue-related illnesses or conditions. The present invention provides anti-fatigue agents that contain andrographolide, optionally in combination with alpha-lipoic acid, as active ingredients, and new oral compositions that contain andrographolide and alpha-lipoic acid. The present invention is useful in preventing or treating chronic fatigue syndrome, overwork, physical fatigue, mental fatigue, and organ fatigue.本發明目的為提供一種對人類或動物等為安全，而且可日常性的持續攝取，具有抗疲勞作用，對於疲勞相關之疾病或狀態之預防或處置為有效之組成物。本發明提供一種含有穿心蓮內酯，並依照需要與α－類脂酸一起作為有效成分之抗疲勞劑，以及含穿心蓮內酯及α－類脂酸之一種新口服組成物。本發明在用於預防或處置慢性疲勞症候群、過勞、肉體性疲勞、精神性疲勞及臟器疲勞之方面為有用的。
