Disclosed is a composition which is safe for a human body and an animal, can be ingestedcontinuously on a daily basis, has an anti-fatigue activity, and is effectivefor the prevention or treatment of a disease or condition associated with fatigue.Specifically disclosed is an anti-fatigue agent comprising andrographolideoptionally together with an α-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide andan α-lipoic acid. The anti-fatigue agent and the oral composition areuseful for the prevention or treatment of chronic fatigue syndrome, overfatigue,physical fatigue, mental fatigue and organ fatigue.