INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN HAVING A PI OF BETWEEN 5.8 AND 8.5 AND A COPOLYAMINO ACID CARRYING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
CHAN, YOU-PING,GEISSLER, ALEXANDRE,NOEL, ROMAIN,CHARVET, RICHARD,LAURENT, NICOLAS
申请号：
CA3084688
公开号：
CA3084688A1
申请日:
2018.12.07
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to compositions which are physically stable in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least: a) a basal insulin whose isoelectric point (pl) is between 5.8 and 8.5 and b) a co-polyamino acid carrying carboxylate charges and at least one hydrophobic radical.L'invention concerne des compositions stables physiquement sous forme d'une solution aqueuse injectable, dont le pH est compris entre 6,0 et 8,0, comprenant au moins : a) une insuline basale dont le point isoélectrique (pl) est compris entre 5,8 et 8,5 et b) un co-polyaminoacide porteur de charges carboxylates et d'au moins un radical hydrophobe.
