PH 7 INJECTABLE SOLUTION COMPRISING AT LEAST ONE BASIC INSULIN WITH A PI BETWEEN 5.8 AND 8.5 AND A CO-POLYAMINOACIDE CARRYING CARBOXYLATE LOADS AND HYDROPHOBIC RADICALS

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专利权人:

ADOCIA

发明人:

ALEXANDRE GEISSLER,SEGOLENE LAAGE,RICHARD CHARVET,OLIVIER SOULA

申请号：

FR1655222

公开号：

FR3052072A1

申请日:

2016.06.07

申请国别(地区):

FR

年份:

2017

代理人:

摘要：

The invention relates to physically stable compositions in the form of an aqueous solution for injection, whose pH is between 6.0 and 8.0, comprising at least: a) a basal insulin whose isoelectric point (pI) is between 5.8 and 8.5 and b) a co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical. [0001] L'invention concerne des compositions stables physiquement sous forme d'une solution aqueuse injectable, dont le pH est compris entre 6,0 et 8,0, comprenant au moins : a) une insuline basale dont le point isoélectrique (pI) est compris entre 5,8 et 8,5 et b) un co-polyaminoacide porteur de charges carboxylates et d'au moins un radical hydrophobe.

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