LUO, Guanglin,CHEN, Ling,DUBOWCHIK, Gene M.,JACUTIN-PORTE, Swanee E.,SIVAPRAKASAM, Prasanna,MACOR, John E.,LUO GUANGLIN,CHEN LING,DUBOWCHIK GENE M,JACUTIN-PORTE SWANEE E,SIVAPRAKASAM PRASANNA,MACOR JO
申请号：
ES14802989
公开号：
ES2693718T3
申请日:
2014.11.03
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I ** Formula ** wherein: R 1 is alkyl, haloalkyl, cycloalkyl, halocycloalkyl alkylcycloalkyl, dialkylcycloalkyl, phenylcycloalkyl, hydroxycycloalkyl or ketocycloalkyl； R2 is hydrogen or alkyl； R3 is hydrogen or alkyl； or N (R2) (R3) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl or azabicycloheptane, and is substituted with 0-4 halo or alkyl substituents； Ar1 is 3-pyridinyl and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, hydroxyalkyl, (hydroxyl) haloalkyl, alkoxyalkyl, alkyl (N (R2) (R3)), benzyl, alkenyl, cycloalkyl, hydroxy , alkoxy, haloalkoxy, (hydroxyl) alkoxy, (alkoxy) alkoxy, (cycloalkyl) alkoxy, phenoxy, alkylcarbonyl, (haloalkyl) carbonyl, phenylcarbonyl, alkoxycarbonyl, carboxy, aminocarbonyl, acetamido, N (R2) (R3) and Ar2； and Ar2 is phenyl, naphthalenyl, pyrrolyl, furanyl, thienyl, pyrrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, indolyl, benzofuranyl, benzothiophenyl or quinolinyl, and is substituted with 0-3 selected substituents between the group consisting of cyano, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylcarbonyl and N (R2) (R3)； wherein "alkyl" means a linear or branched alkyl group composed of from 1 to 6 carbon atoms； "alkenyl" means a linear or branched alkyl group composed of from 2 to 6 carbon atoms with at least one double bond； "cycloalkyl" means a monocyclic ring system composed of from 3 to 7 carbon atoms； or a pharmaceutically acceptable salt thereof.Un compuesto de formula I**Fórmula** donde: R1 es alquilo, haloalquilo, cicloalquilo, halocicloalquilo alquilcicloalquilo, dialquilcicloalquilo, fenilcicloalquilo, hidroxicicloalquilo o cetocicloalquilo； R2 es hidrogeno o alquilo； R3 es hidrogeno o alquilo； o N(R2)(R3) tomado conjuntamente es azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo o azabicicloheptano, y esta sustituido con 0-4 sustituyentes h
