COWLEY PHILLIP,WISE ALAN,DAVIS SUSAN,KICZUN MICHAEL
申请号:
IN201647033993
公开号:
IN201647033993A
申请日:
2016.10.04
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
12345123457123456 666Provided is a tryptophan 2 3 dioxygenase (TDO) and/or indoleamine 2 3 dioxygenase (IDO) inhibitor compound for use in medicine which compound comprises the following formula: wherein X X X X and X may be the same or different and each is independently selected from C N and O each atom having a dotted line may independently have a double bond or a single bond provided that valencies at each atom are maintained each R R R R R and R may be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group provided that the number of such R groups present is such that the valencies of X X X X and X are maintained one or two Rgroups may be present and are selected from H and a substituted or unsubstituted organic group provided that the number of R groups present is such that the valency of the carbon atom to which they are attached is maintained and provided that at least one R is an organic group comprising an atom double bonded to an oxygen atom (preferably a carbonyl group or a sulphonyl group) at an a ß or ? position to the carbon atom to which the R is attached and in which the atom double bonded to an oxygen atom is also bonded to a hetero atom.