TURDI, Huji,HANGELAND, Jon J.,LAWRENCE, R. Michael,CHENG, Dong,AHMAD, Saleem,MENG, Wei,BRIGANCE, Robert Paul,DEVASTHALE, Pratik,ZHAO, Guohua
申请号：
ES12821212
公开号：
ES2584070T3
申请日:
2012.11.30
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a solvate thereof, in which: indicates a single or double bond； x and y can both be a simple link； when x is a double bond, then y is a simple bond and R4 and R16 are absent； when y is a double bond, then x is a simple link and R5 and R16 are absent； R1 is independently selected from the group consisting of: -CONH (C4-18 alkyl), -CONH-C2-8 haloalkyl, -CONH (CH2) 1-8Ph, -CONHCH2CO-C2-8 alkyl, - (CH2) m - (C3-10 carbocycle substituted with 0-2 Rb and 0-2 Rg), - (CH2) m- (5-6 membered heteroaryl comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S, wherein said heteroaryl is substituted with 0-1 Rb and 0-2 Rg) and a C1-12 hydrocarbon chain substituted with 0-3 Ra； wherein said hydrocarbon chain can be linear or branched, saturated or unsaturated； R2 is independently selected from the group consisting of: C1-4 alkyl, C3-4 cycloalkyl and C1-4 haloalkyl； R3 is independently selected from the group consisting of: H, F, Cl, C1-4 alkyl and CN； R4 and R5 are independently selected from the group consisting of: H, F, Cl and C1-4 alkyl； when x is a simple bond, R3 and R4 can be combined with the carbon atom to which they are attached to form a 3 to 6 member carbocycle； R6 is independently selected from the group consisting of: H, halo, C1-4 alkyl, NO2, Rc, - (CH2) n- (X) t- (CH2) mRc, NH2, -CONH (C1-6 alkyl) , -NHCOX1SO2Rj, -NHCOCH2PO (OEt) 2, -NHCOCORj, - NHCOCH (OH) Rj, -NHCOCH2CORj, -NHCONHRj and -OCONRfRj； X is independently selected from the group consisting of: O, S, NH, CONH and NHCO； X1 is independently a C1-4 hydrocarbon chain optionally substituted with C1-4 alkyl or C3-4 cycloalkyl； when y is a simple bond, R5 and R6 can be combined with the carbon atom to which they are attached to form a 3 to 6 member carbocycle； R11, R12, R13, R14 and R15 are independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-2
