MICHAELA BAIRLEIN,PHILIP LIENAU,FRANZISKA SIEGEL,NINGSHU LIU,VOLKHART MIN LI,ECKHARD JIAN - BENDER,SIMON HOLTON,DETLEV SLZLE,PHILIPP BUCHGRABER,SARAH WAGNER,JENS ACKERMANN,KNUT EIS,FRANZ VON NASSBAUM
申请号：
ARP160101258
公开号：
AR104513A1
申请日:
2016.05.03
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Cyclohexane compounds with substituted amides, method for the preparation of these Compounds, Intermediates useful for preparing such Compounds, Pharmaceutical compositions comprising such compounds and combinations and the use of such compounds for Elaborac Ion of a Pharmaceutical composition for the Treatment or prophylaxis of a diseaseIn particular, Neoplasms, as a Single Agent or in combination with other active ingredients.Claim 1: a compound of formula (1), where a represents a group selected from compounds of formula (2), (3) and (4) where * indicates the point of Union of these groups with the rest of the Molecule, where this point is an Atom carbon； Compound d Formula (4) and represents a bicyclic Aromatic Ring System.Where the C ring is a heteroaryl Group Member 5 contains a group containing a heteroatom n, NH, and N (c u2081 u208b u2083 - alkyl), where one or two carbon Atoms are also optionally substituted by one or two n Atoms of the C ring is optionally replacing Gone with one or two groups r u2075,And the Ring D represents a phenyl group or a heteroaryl Group of 6 members that contains One, two, or three heteroatoms (Nitrogen, where the ring is optionally substituted with one, two or three groups r u00b9 u00b2； x u00b9 represents nr u00b3 or； r u00b9 represents a group selected from: - or u00b9 u00b3, and - N (r u00b9 u2074) r u00b9 u2075； R u00b2 represents a group selected from Hydrogen, alkyl c u2081 u208b u2083,- and c u2083 u208b u2084 cycloalkyl； r u00b3 represents a hydrogen Atom, r u2074 represents a hydrogen Atom, r u2075 represents independently in each case, a group to select from: Halogen, Hydroxy, c u2081 u208b u2084 alkyl, cycloalkyl c u2083 u208b u2084 c u2081 u208b u2083 alkoxy -, -, - haloal c u2081 u208b u2083 Coxi, N (r u00b9 u2078 r u00b9 u2079) -, - C (o) r u00b9 u00b3, and - C (o) or u00b9 u00b3, where c u2081 u208b u2084 is optionally substituted alkyl,Two or three times with a group to select independently in each case, from Ha
