The invention concerns a method for preparing a plasma product depleted of one or more thrombogenic factors, comprising the combination of at least two steps chosen from among an ethanol fractionation step, a filtration-adsorption step, a precipitation step with caprylic acid and a chromatography step on ion exchange resin.本發明關於一種製備缺乏一或多種致血栓因子之血漿製品的方法,包括至少二個步驟的組合擇自於乙醇分級分離步驟、過濾-吸附步驟、辛酸沉澱步驟、以及離子交換樹酯之層析步驟。