Arbutus Biopharma Corporation;The University of British Columbia;Alnylam Pharmaceuticals
发明人:
申请号：
EP16163003.3
公开号：
EP3100718A1
申请日:
2008.12.31
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
