ARBUTUS BIOPHARMA CORPORATION;THE UNIVERSITY OF BRITISH COLUMBIA
发明人:
HOPE, MICHAEL J.,SEMPLE, SEAN C.,CHEN, JIANXIN,MADDEN, THOMAS D.,CULLIS, PIETER R.,CIUFOLINI, MARCO A.,MUI, BARBARA
申请号：
CA2984026
公开号：
CA2984026C
申请日:
2009.10.09
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
