The present invention relates to a pyrrole-substituted indolone derivative, a preparation method therefor, a composition comprising same and a use thereof. The pyrrole-substituted indolone derivative has a structure represented by general formula (I). The present invention further relates to a use of the pyrrole-substituted indolone derivative in treating receptor tyrosine kinase mediated diseases and a pharmaceutical composition containing a compound of such structure for treating diseases related to tumor and the like.