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Process for preparing oligomers
专利权人:
SAREPTA THERAPEUTICS; INC.
发明人:
申请号:
ARP170101415
公开号:
AR108588A1
申请日:
2017.05.24
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
In the present processes are provided for preparing an oligomer (For example, a morpholino oligomer).The Synthetic processes described in this can be advantageous to increase the oligomeros\u00edntesis while keeping the overall yield and Purity Of synthesized oligomer.In addition compounds.Claim 1, a process for preparing an oligomeric Compound of formula (1), where n is an integer from 10 to 40, and each R\u00b2 is selected independently for each occurrence.The group is the group of compounds of the formula (2),Where the process involves the Sequential steps of: (a) contacting a compound of formula (3), where r\u00b9 is a means of support and r\u00b3 is selected from the group consisting tritilo,Monometoxitritilo,Dimetoxitritilo and trimetoxitritilo with release Agent to form the compound of formula (4), where r\u00b9 is a means of support (b) contacting the compound of formula (4) with a CComprised of formula (5), where r\u00b3 is selected from the group consisting tritilo, monometoxitritilo,Dimetoxitritilo and trimetoxitritilo to form a compound of formula (6), where r\u00b9 is a means of support, and r\u00b3 is selected from the group consisting tritilo, monometoxitritilo,Dimetoxitritilo and trimetoxitritilo (c) contacting the compound of formula (6) with a release Agent to form a compound of formula (7), where r\u00b9 is a means of support (d)R in the compound of formula (7) with a compound of formula (8) where r\u00b3 is selected from the group consisting tritilo, monometoxitritilo, dimetoxitritilo and trimetoxitritilo,And r\u2074 is selected from the group consisting of compounds of Formulae (9) to form a compound of formula (10) where r\u00b9 is a support MediumR\u00b3 is selected from the group consisting tritilo, monometoxitritilo, dimetoxitritilo and trimetoxitritilo,And r\u2074 is selected: group compounds of Formulae (9) (e) n-1 iterations of the Sequential steps of: (a) contacting the product formed by the step immediately previOr with a release Agent
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