1 - quinuclidine acid Esters can be used as azaheterociclilacetico Antimuscarinic agents, Process for preparing and medicinal compositions containing same
Compounds of formula (1), which can act as Selective m3 receptors antagonists, Process for preparing the composition which comprises, and their use in therapy. These compounds can be used to treat Respiratory Diseases like Asthma or COPD, among others.Claim 1: a quinuclidin u00e9ster acid 1 - azaheterociclilac u00e9tico is characterized because of General formula (1): can be a simple or Double Union, Union,, S, so, SO u2082, nr u00b3, C (r u00b3) r u2074, co, C (o) n (r u00b3), N (C (r u00b3) or, so u2082n (r u00b3), N (C (r u00b3) or oC (n), (o) r u00b3), N (SO u2082, r u00b3)(C r u00b3) = C (r u2074) and C (r u00b3) - (ch u2082) - C (r u2074)； M is an integer between 1 and 4； n is 0 or an integer between 1 and 4； r u00b9 is selected from the group consisting c u2081 u208b u2081 u2080 c u2083 u208b u2088 alkyl, cycloalkyl, aryl, heteroaryl, aryl - c u2081 u208b u2086 c u2081 u208b u2086 heteroaryl alkyl and alkyl, optionally substituted With one or more substituents selected from the group consisting of halogen ATOMS, oxo (= o) Oh, sh, no u2082, CN, ( u2082, r u00b3)COOH, co u2082r u00b3, cf u2083, alcoxicarbonilo c u2081 u208b u2081 u2080, alquilsulfanilo c u2081 u208b u2081 u2080, alquilsulfinilo c u2081 u208b u2081 u2080, alquilsulfonilo c u2081 u208b u2081 u2080, c u2081 u208b u2081 u2080 c u2081 u208b u2081 u2080 alkyl, alkoxyl,Ariloxi and heteroaryl； x u207b anion is a physiologically acceptable； R u00b2 is a group of formula: ( u209a ch u2082) - - - - - - - - - - (ch u2082 W q) where p is 0 or an integer between 1 and 4； Q is 0 or an integer between 1 and 4； p is absent or is selected from the group consisting of o, S, so, SO u2082, co, nr u00b3, CH = CH, N (SO u2082 r u00b3), N (r u00b3 COO), N (r u00b3) C (o), so u2082n (r u00b3)Co (o) n (r u00b3) and C (o) n (r u00b3)； W is selected from the group consisting of H, c u2081 u208b u2081 u2080 c u2081 u208b u2081 u2080 alkoxyl alkyl, cycloalkyl, aryl, heteroaryl, c u2083 u208b u2088, heterocicloalquilo c u208
