A knee brace for continual electro-acupuncture stimulation system comprises: a first electrode configured to electrically coupled to acupuncture point Heting “(S 156)”; a second electrode configured to electrically coupled to acupuncture point “Spleen 10 ”; a third electrode configured to electrically coupled to acupuncture point “Stomach 34 ”; a fourth electrode configured to electrically coupled to acupuncture point “Hsiyen (S 145)”; a fifth electrode configured to electrically coupled to acupuncture point “Stomach 35 ”; a sixth electrode configured to electrically coupled to acupuncture point “Bladder 40 ”. The first, second, and third electrodes are connected to a polarity of voltage, and the fourth, fifth, and sixth electrodes are connected to an opposite polarity of voltage, such that electric currents flow in a body of a patient to achieve analgesia, cartilage repair and regeneration in the knee joint.