LLC;CALITOR SCIENCES, LLC;CALITOR SCIENCES;SUNSHINE LAKE PHARMA CO., LTD.
发明人:
XI, NING
申请号：
SG11201502725T
公开号：
SG11201502725TA
申请日:
2013.11.10
申请国别(地区):
SG
年份:
2015
代理人:
摘要：
The present invention provides heteroaromatic derivatives of formula (I) and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
