The present invention relates to be used as PI3K(phosphatidylinositol-3-kinases) inhibitor oxazolidine -2- ketone replace pyrimidine compound and its Pharmaceutical composition, produce they method and its treatment rely on what PI3K illness, disease and not moderate purposes.本發明涉及用作PI3K(磷脂酰肌醇‑3‑激酶)抑制劑的噁唑烷‑2‑酮取代的嘧啶化合物及其藥用組合物、生産它們的方法及其在治療依賴於PI3K的病症、疾病和不適中的用途。