抗緩激肽B1受體配位體之抗體农业专利-农业专业知识服务系统

发明人:: LI, HAN,李汉,李漢,KOMINOS, DOROTHEA,可米诺斯　多罗西,可米諾斯　多羅西,ZHANG, JIE,张杰,張杰,PRITSKER, ALLA,皮斯克　亚拉,皮斯克　亞拉,DAVISON, MATTHEW,达威森　马修,達威森　馬修,BAURIN, NICOLAS,宝林　尼可拉斯,寶林　尼可拉斯,SUBRAMANIAN, GOVINDAN,瑟柏马尼安　高威丹,瑟柏馬尼安　高威丹,可米诺斯多罗西,可米諾斯多羅西,皮斯克亚拉,皮斯克亞拉,达威森马修,達威森馬修,宝林尼可拉斯,寶林尼可拉斯,瑟柏马尼安高威丹,瑟柏馬尼安高威丹

摘要：: The invention provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-Kallidin or des-Arg10-Kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to modulate Kallidin or des-Arg10-Kallidin activity or detect Kallidin or des-Arg10-Kallidin or, either in vitro or in vivo, are also provided by the invention. The invention further provides methods of making antibodies that specifically bind to des-Arg9- Bradykinin and des-Arg10-Kallidin-like peptide.本發明提供特異性結合至胰激肽或去-Arg10-胰激肽之抗體。本發明亦提供藥物組合物，以及編碼抗胰激肽或抗去-Arg10-胰激肽抗體之核酸、重組表現載體及用於製備此等抗體或其片段之宿主細胞。本發明亦提供在活體外或活體內使用本發明抗體調節胰激肽或去-Arg10-胰激肽活性或檢測胰激肽或去-Arg10-胰激肽之方法。本發明進一步提供製備特異性結合至去-Arg9-緩激肽及去-Arg10-胰激肽樣肽之抗體的方法。