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LIPIDE CATIONIQUE
专利权人:
LTD.;EISAI R&D MANAGEMENT CO.
发明人:
SUZUKI, YUTA,TAKAHASHI, YOSHINORI
申请号:
CA3020271
公开号:
CA3020271A1
申请日:
2017.06.22
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present invention provides a cationic lipid which is able to be used fornucleic aciddelivery to the cytoplasm. A cationic lipid according to the present inventionis, forexample, a compound represented by formula (1a) or a pharmaceuticallyacceptable saltthereof. (In formula (1a), each of L1 and L2 independently represent analkylene grouphaving 3-10 carbon atoms; each of R1 and R2 independently represent an alkylgrouphaving 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X1represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to(P-5).)(In formulae (P-1) to (P-5), R3 represents an alkyl group having 1-3carbon atoms.)(see formula 1a,)(see formula P-1)(see formula P-2)(see formula P-3)(see formula P-4)(seeformula P-5)
来源网站:
中国工程科技知识中心
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