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N-alkylaryl-5-oxyaryl-octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b
专利权人:
Cadent Therapeutics Inc.
发明人:
Anderson, David,Volkmann, Robert,Menniti, Frank
申请号:
NZ72956915
公开号:
NZ729569A
申请日:
2015.09.23
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment of neurological diseases having the Formula I where R1, R2, L1, L2, X, Y, and Y’ are described therein. In an aspect, compounds of formula I are described and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautotmers, or stereoisomers thereof wherein: L1 is straight or branched C1-C5 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, OR10, NH2, NHR10, and N(R10)(R10’) provided that no more than one oxygen or nitrogen is attached to any carbon.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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