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LIPIDE CATIONIQUE
专利权人:
Eisai R&D Management Co.; Ltd.
发明人:
SUZUKI Yuta,TAKAHASHI Yoshinori
申请号:
EP17815482
公开号:
EP3476832A4
申请日:
2017.06.22
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1a) or a pharmaceutically acceptable salt thereof. (In formula (1a), each of L 1 and L 2 independently represent an alkylene group having 3-10 carbon atoms; each of R 1 and R 2 independently represent an alkyl group having 4-22 carbon atoms or an alkenyl group having 4-22 carbon atoms; X 1 represents a single bond or -CO-O-; and ring P represents one of formulae (P-1) to (P-5).)(In formulae (P-1) to (P-5), R 3 represents an alkyl group having 1-3 carbon atoms.)
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