CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE MONTPELLIER 2;INSTITUT CURIE;ABIVAX
发明人:
TAZI, JAMAL,MAHUTEAU, FLORENCE,NAJMAN, ROMAIN
申请号：
CU20150024
公开号：
CU24245B1
申请日:
2015.03.17
申请国别(地区):
CU
年份:
2017
代理人:
摘要：
The invention refers to a compound (I), which has the following formula: the space of frumula I: Z is n or C, y is n or C, W is n or C, t is n or C, u is n or C, O is n or C, which is alternatively selected in the space of formula compound (1), wherein R independently represents hydrogen atom, Halogen atom or a group of atoms selected from a group of (C1-C3) tar,A set of alcoxi (C1-C4),a -CN group, a hydroxyl group, a -COOR1 group, a C1-C3 fluoroalkyl group, a C1-C3 fluoroalkoxy group, a -NO2 group and a -NR1R2 group； n is 1 or 2； n ’is 1 or 2； R '' is a hydrogen atom or a (C1-C4) alkyl group, R 'is a hydrogen atom or a (C1-C3) alkyl group, a -NO2 group, a -NR1R2 group and a C1 alkoxy group -C4； R1 and R2 are independently a hydrogen atom or a C1-C3 alkyl group； with the proviso that when R 'is a hydrogen atom, R independently represents a halogen atom or a group selected from a (C1-C3) alkyl group,A group alcoxi (C1-C4),One group, one hydroxyl group, one groupA fluoropropyl compound (C1-C3),A group of C1-C3 halothanes,One group - individual (C1-C3)and a group -N ((C1-C3) alkyl) 2. And the compounds of formula (2) SPACE FOR FORMULA Wherein: R 'is a hydrogen atom or a group selected from a group (C1-C3) alkyl, a halogen atom a hydroxyl group a group -COOR1, a group - NO2, a group -NR1R2,A set of alcoxi (C1-C4),A morpholin group and a group - "CN"； R "is a hydrogen atom or a group (C1-C4) asphalt, R1 and R2 are an independent hydrogen atom or an asphalt group (C1-C3). It is used to prevent, inhibit or treat pathological or non pathological diseases related to early aging.La presente invención se refiere a un compuesto (I) que tiene la siguiente fórmula: ESPACIO PARA FÓRMULA I Donde: Z es N o C, Y es N o C, W es N o C, T es N o C, U es N o C. El cual es alternativamente seleccionado entre los compuestos de fórmula (1) ESPACIO PARA FÓRMULA Donde: R independientemente representa un átomo de hidrógeno, átomo de halógeno o un grupo seleccionado de entre un grupo (C1-C3)alq
