A method and apparatuses are provided that use a neural network to correct artifacts in computed tomography (CT) images, especially cone-beam CT (CBCT) artifacts. The neural network is trained using a training dataset of artifact-minimized images paired with respective artifact-exhibiting images. In some embodiments, the artifact-minimized images are acquired using a small cone angle for the X-ray beam, and the artifact-exhibiting images are acquired either by forwarding projecting the artifact-minimized images using a large-cone-angle CBCT configuration or by performing a CBCT scan. In some embodiments, the network is a 2D convolutional neural network, and an artifact-exhibiting image is applied to the neural network as 2D slices taken for the coronal and/or sagittal views. Then the 2D image results from the neural network are reassembled as a 3D imaging having reduced imaging artifacts.
