Daniela Alberati,Edilio Maurizio Borroni,Thomas Hartung,Roger David Norcross,Emmanuel Pinard
申请号：
US12607111
公开号：
US08153679B2
申请日:
2009.10.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality.whereinR1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy andR2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. The radiolabelled compounds of formula I may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality.
