Jay W. Pettegrew,Richard J. McClure,Kanagasabai Panchalingam
申请号：
US12178281
公开号：
US08329142B2
申请日:
2008.07.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds, compositions and methods for the detection and diagnosis of Parkinsons disease. Derivative lycerophosphocholine (GPC) compounds are used as a detection and diagnostic aid to measure progression of Parkinsons disease by detecting GPC binding to α-synuclein. Derivative CPG compounds including non-radioactive, paramagnetic, and radioactive derivatives of GPC are presented. These compounds possess similar binding properties to original GPC molecules and are useful in medical magnetic resonance imaging (MRI) and/or positron emission tomography (PET) applications. By employing these radiological techniques in conjunction with the compositions of the present invention, the detection, diagnosis and assessment of the progression of Parkinsons disease may be achieved.
