OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU "NEWVAC" (OOO "NEWVAC")
发明人:
IVASHCHENKO, Andrey Alexandrovich,ИВАЩЕНКО, Андрей Александрович,SAVCHUK, Nikolay Filippovich,САВЧУК, Николай Филиппович,TKACHENKO, Sergey Yevgenievich,ТКАЧЕНКО, Сергей Евгеньевич
申请号：
RURU2014/000514
公开号：
WO2015/020565A1
申请日:
2014.07.11
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
This invention relates to novel compounds - substituted [1,2,4]-triazolo[4,3-а]pyridines of general formula (I), or the pharmaceutically acceptable salts thereof, where A is an unsubstituted or substituted aminocarbonyl group -N-С(О)-, an acylamino group or aminocarbonyl В is a non-aromatic cyclic substituent selected from С4-С6 cycloalkyl an aromatic cyclic substituent selected from phenyl, which can be substituted by halogen, C1-С3 alkoxy a non-aromatic 5-6 membered heterocyclic substituent with a nitrogen atom as the hetero atom, and possibly N-substituted C1-С3 alkyl an aromatic 5-6 membered heterocyclic substituent in which the hetero atoms are selected from nitrogen, oxygen or sulphur, and which can be substituted by C1-С6 alkyl or an aromatic 5-6 membered heterocyclic substituent in which the hetero atom is selected from nitrogen condensed with a benzene ring R1a, R1b and R1c are independently Н, С1-С3 alkoxy. These compounds exhibit antagonistic activity in relation to adenosine A2A receptors. The invention also relates to the use of said compounds as an active component for pharmaceutical compositions, drugs and adjuvants. The invention also relates to methods for treating disorders in the function of the central nervous system (CNS) and neuro-degenerative, inflammatory, infectious and oncological diseases.Linvention concerne de nouveaux composés consistant en des [1,2,4]triazolo[4,3-A]pyridines substitués correspondant à la formule générale (I), ou leurs sels pharmaceutiquement acceptables, où : A représente un groupe aminocarbonyle -N-С(О)- éventuellement substitué, un groupe acylamino ou aminocarboynle B représente un substituant cyclique non aromatique choisi parmi С4-С6 cycloalkyle, un substituant aromatique cyclique choisi parmi phényle pouvant être substitué par un halogène, C1-С3 alcoxy, un substituant non aromatique à 5-6 membres hétérocyclique avec un atome dazote en qualité dhétéroatome, et un alkyle C1-С3 potentiellement substitué en N, un sub
